Lp(a) elevated

Lp(a) elevated (≥50 mg/dL or ≥125 nmol/L)? Yes

Recommendationlpa-elevatedFewer than 5 people have reached this rule so far

No approved Lp(a)-lowering drug (first outcomes trial negative, Sept 2026) — counts as a risk enhancer and favours intensifying LDL-lowering

Clinical review

All reviewers

No clinician has signed off this rule yet. It reflects our reading of the guidelines cited below, which has not been independently checked.

What someone who reaches this rule is told

This is a routing step: it says nothing itself, and decides which rule applies next. For the example person, that is Lp(a) elevated, not very high.

An example person who reaches it

“Borderline risk + high Lp(a)” — an illustrative profile, not a real user.

58-year-old manBP 132/82LDL 140Lp(a) 78 mg/dL10-yr PREVENT-ASCVD 4.9%

Their path through lp(a)

Lp(a) elevated (≥50 mg/dL or ≥125 nmol/L)?Yes ← this rule
Very high (≥100 mg/dL or ≥250 nmol/L)?No — elevated but not extreme

Where it sits

Then asks: Very high (≥100 mg/dL or ≥250 nmol/L)?

Review this rule

For practising clinicians. Endorse it, propose a change, or dispute it. We verify every reviewer before a review is shown, and a review stays attached to the version of the rule you saw — if the rule changes, the page says so. You'll be asked to declare any relevant interests; they're shown with your review.

Runs in lib/engine/lpaFlag.ts as lpa-elevated.